adult onset still's disease with different antibodies: a case report and review of literature

adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. there is not currently any specific serological markers for aosd , and  diagnosis still relying on the exclusion of other likely diagnoses. yamaguchi’s criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus erythematosus and rheumatoid arthritis. here we report a 28-year-old woman with arthralgia, fever, rash, leukocytosis, lymphadenopathy, sore throat, abnormal liver function and negative rheumatoid factor and ana but  seropositive for anti-ccp, anti-dsdna, and c-anca. it seems that despite aosd is considered as a seronegativedisorder; it should be remembered in patients with compatible findings who are seropositive.